Application of novel CAR technologies to improve treatment of autoimmune disease
Application of novel CAR technologies to improve treatment of autoimmune disease
Blog Article
Chimeric antigen receptor (CAR) T cell therapy has become an important treatment for hematological cancers, and its success has spurred research into CAR T cell therapies for other diseases, SALTY DOG including solid tumor cancers and autoimmune diseases.Notably, the development of CAR-based treatments for autoimmune diseases has shown great progress recently.Clinical trials for anti-CD19 and anti-BCMA CAR T cells in treating severe B cell-mediated autoimmune diseases, like systemic lupus erythematosus (SLE), have shown lasting remission thus far.CAR T cells targeting autoreactive T cells are beginning clinical trials for treating T cell mediated autoimmune diseases.
Chimeric autoantigen receptor (CAAR) T cells specifically target and eliminate only autoreactive B cells, and they have shown promise in treating mucosal pemphigus vulgaris and MuSK myasthenia gravis.Regulatory CAR T cells have also been developed, which show potential in altering autoimmune affected areas by creating a protective barrier as well as helping decrease inflammation.These new treatments are only the beginning of potential CAR T cell applications in treating autoimmune disease.Novel CAR technologies have been developed that increase the safety, potency, specificity, and efficacy of CAR T cell therapy.
Applying these novel modifications to autoimmune CARs has the potential to enhance the efficacy and applicability of SAC À DOS CAR therapies to autoimmune disease.This review will detail several recently developed CAR technologies and discuss how their application to autoimmune disease will improve this emerging field.These include logic-gated CARs, soluble protein-secreting CARs, and modular CARs that enable CAR T cell therapies to be more specific, reach a wider span of target cells, be safer for patients, and give a more potent cytotoxic response.Applying these novel CAR technologies to the treatment of autoimmune diseases has the potential to revolutionize this growing application of CAR T cell therapies.